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Kastro-Kyllini (Greek: Κάστρο-Κυλλήνη) is a former municipality in Elis, West Greece, Greece. Since the 2011 local government reform it is part of the municipality Andravida-Kyllini, of which it is a municipal unit. The municipal unit has an area of 49.322 km2. The population was 3,622 in 2011. The municipality Kastro-Kyllini was created in 1999 as part of the Kapodistrias reform from the formerly independent communities Kyllini, Kato Panagia, Kastro and Neochori, that became municipal districts. After the 2011 Kallikratis reform, these municipal districts became (dependent) communities. Its seat of administration was the small port town of Kyllini.